澳门新葡8455最新网站-点击进入

澳门新葡8455最新网站

澳门新葡8455最新网站-点击进入生命科学学院

生命科学联合中心

学术报告

 

题目:Transcriptional regulation in cardiovascular system development and disease

 

报告人:William T. Pu, M.D.

Professor of Pediatrics

Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, USA

 

时间:2016622日(星期三)下午1:00-2:30

 

地点:澳门新葡8455最新网站-点击进入金光生命科学大楼101报告厅

 

Host:澳门新葡8455最新网站    何爱彬 (Tel. 6276-7275)

 

摘要: Formation and function of the cardiovascular system is under exquisite transcriptional control. Using a combination of functional genetic, transcriptomic, and epigenomic approaches the Pu lab has been investigating the molecular mechanisms of transcriptional regulation in the heart and vascular systems. In this talk I will summarize some of the findings: (1) mapping of dynamic changes in transcription factor complexes and binding sites through heart development and disease; (2) post-transcriptional regulation of transcription factor complexes in and their effects on heart growth; and (3) development of a Cre-directed method for cell type specific enhancer identification and its application to studying transcriptional regulation of blood vessel formation and homeostasis.