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曹慧青 副研究员 阅读次数:

曹慧青 副研究员

M.D. Ph.D. 博士生导师

核酸技术研究室Co-PI

联系电话: 010-62769861

E-mail: caohuiqing@pku.edu.cn

通讯地址:澳门新葡8455最新网站-点击进入新生命科学大楼239室 100871
 

1994年 毕业于山东泰山医学院临床医学专业,获医学学士学位;1998年毕业于同济医科大学实验医学研究中心,获硕士学位;2001年于中国协和医科大学阜外心血管病澳门新葡8455获理学博士学位并留校工作两年。2004-2006年在美国田纳西大学卫生科学中心生理系作博士后研究并晋升为研究助理。自2007年2月任澳门新葡8455最新网站副研究员。主持或参加多项国家自然基金面上项目、重点项目以及科技部“973”项目等。

主要研究兴趣:心血管疾病相关基因的功能研究。

代表论文:

1. Zhao L, Yang F, Xu K, Cao H, Zheng GY, Zhang Y, Li J, Cui H, Chen X, Zhu Z, He H, Mo X, Kennedy BK, Suh Y, Zeng Y, Tian XL. Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging Cell. 2012 Dec;11(6):1094-101

2. Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian XL, Vaupel JW. Effects of FOXO genotypes on longevity: a biodemographic analysis.J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1285-99

3. Li Y, Wang WJ, Cao H,Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y, Tian XL.Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.Hum Mol Genet. 2009 Dec 15;18(24):4897-904(co-first author)

4. Wang D, Liu Z, Li Q, Karpurapu M, Kundumani-Sridharan V, Cao H, Dronadula N,Rizvi F, Bajpai AK, Zhang C, Müller-Newen G, Harris KW, Rao GN. An essential role for gp130 in neointima formation following arterial injury. Circ Res. 2007 Mar 30;100(6):807-16.

5. Feng Y, Cao HQ, Liu Z, Ding JF, Meng XM. Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K. Gen Physiol Biophys. 2007 Jun;26(2):104-9.

6. Cao H, Dronadula N, Rizvi F, Li Q, Srivastava K, Gerthoffer WT, Rao GN. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Circ Res. 2006 Apr 14; 98(7):913-22

7. Cao H, Dronadula N, Rao GN. Thrombin induces the expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling Axis leading to DNA synthesis and molility in vascular smooth muscle cells. Am J Physiol cell physiol. 2006 Jan;290(1):C172-82.

8. Zhang B, Cao H, Rao GN. 15(S)-hydroxyeicosatetraenoic acid induces angiogenesis via activation of PI3K-Akt-mTOR-S6K1 signaling. Cancer Res. 2005 Aug 15;65(16):7283-91.

9. Zhang B, Cao H, Rao GN. Fibroblast growth factor-2 is a downstream mediator of PI3K-AKT signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. J.Biol.Chem . 2006 Jan 13;281(2):905-14.

10. Dronadula N, Liu Z, Wang C, Cao H, Rao GN.STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motility. J Biol Chem. 2005, 28;280(4):3112-20.

11. Cao HQ, Meng XM, Liu DQ, Zhao XW, Ding JF. Killing effect of coexpressing cytosine deaminase and thymidine kinase on rat vascular smooth muscle cells. Chin Med J (Engl). 2004 Oct;117(10):1464-70.

12. Zhao Y, Xianmin meng,Cao HQ, Ding JF. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J Mol Med. 2003 May;81(5):297-304.

13. Zhao Y, Wei YJ, Cao HQ, Ding JF. Molecular Cloning of NELIN, a Putative Human Cytoskeleton Regulation Gene. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2001;33(1):19-24.

14. Meng XM, Zhao Y, Wei YJ, Cao HQ, Zhao XW, Liu DQ, Shi N, Ding JF. Cloning and characterization of a novel cardiac-specific kinase gene p93 related to sarcomere. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Dec;35(12):1083-9.

15. Feng Y, Liu Z, Cao H, Meng X, Qu Z, Xiong M, Deng Z. Construction of eukaryotic expression plasmid of human PRX3 and its expression in HEK-293FT cells. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):311-3, 321.

16. Wang Z, Cao HQ, Feng Y et al. Characteristics of the binding features of Nelin with F-actin and screening Nelin interactive proteins. Chinese Science Bulletin 2004;49(23):2487-2490.