澳门新葡8455最新网站-点击进入

朱小君 副研究员 阅读次数:

朱小君 副研究员

心血管发育学研究室Co-PI

 

联系电话:010-6275-5291

E-mail: zhuxiaojun@ pku.edu.cn

通讯地址:澳门新葡8455最新网站-点击进入新生命科学大楼236室 100871

 

1992年至2000年在北京医科大学心血管基础澳门新葡8455工作;2000年至2003年在美国Morehouse School of Medicine的心血管澳门新葡8455工作,2003年 至2005年在澳门新葡8455最新网站-点击进入医学部心血管澳门新葡8455工作。2005年10月至今在澳门新葡8455最新网站工作。目前主要从事小G蛋白Rad在心血管系统中的功能研究,主要关注Rad蛋白在心肌细胞肥大、凋亡、心肌纤维化及心血管系统发育和再生中的作用及其机理。

 

代表论文

1. Zhang J, Chang L, Chen C, Zhang M, Luo Y, Hamblin M, Villacorta L, Xiong JW,Chen YE, Zhang J, Zhu X. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. Cardiovasc Res. 2011;91(1):90-8.

2. Sun Z, Zhang J, Zhang J, Chen C, Du Q, Chang L, Cao C, Zheng M, Garcia-Barrio MT, Chen YE, Xiao RP, Mao J, Zhu X. Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase. Biochem Biophys Res Commun. 2011;409(1):52-7.

3. Luo Y, Zhang M, Zhang J, Zhang J, Chen C, Chen YE, Xiong JW, Zhu X. Platelet-Derived Growth Factor Induces Rad Expression through Egr-1 in Vascular Smooth Muscle Cells. PLoS One. 2011;6(4):e19408. 4. Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Circ Res. 2010;106(2):317-27.(并列第一作者)

5. Zhu X, Lin Y, Bacanamwo M, Chang L, Chai R, Massud I, Zhang J, Garcia-Barrio MT, Thompson WE, Chen YE. Interleukin-1 beta-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells. Cardiovasc Res. 2007 Oct 1;76(1):141-8. (责任作者)

6. Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation. 2007;116(25):2976-83.

7. Fu M, Zhang J, Tseng YH, Cui T, Zhu X, Xiao Y, Mou Y, De Leon H, Chang MM, Hamamori Y, Kahn CR, Chen YE. Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation. 2005;111(8):1071-7.

8. Wang Q, Zhu X, Xu Q, Ding X, Chen YE, Song Q. Effect of C-reactive protein on gene expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2005;288(4):H1539-45. (并列第一作者)

9. Lin Y, Zhu X, McLntee FL, Xiao H, Zhang J, Fu M, Chen YE. Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004;24(2):257-63. (并列第一作者)

10. Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE. Egr-1 target genes in human endothelial cells identified by microarray analysis. Gene. 2003;315:33-41. (并列第一作者)

11. Chen YE, Fu M, Zhang J, Zhu X, Lin Y, Akinbami MA, Song Q. Peroxisome proliferator-activated receptors and the cardiovascular system. Vitam Horm.2003;66:157-88. Review.

12. Zhu X, Lin Y, Zhang J, Fu M, Mao Z, Chen YE. Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells. Cell Mol Life Sci. 2003;60(1):212-8.

13. Fu M, Zhang J, Lin Y, Zhu X, Zhao L, Ahmad M, Ehrengruber MU, Chen YE. Early stimulation and late inhibition of peroxisome proliferator-activated receptor gamma (PPAR gamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads. Biochem J. 2003;370(Pt 3):1019-25.

14. Zhang J, Fu M, Myles D, Zhu X, Du J, Cao X, Chen YE. PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways. FEBS Lett. 2002;521(1-3):180-4.

15. Fu M, Zhang J, Lin Yg Y, Zhu X, Willson TM, Chen YE. Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells. Biochem Biophys Res Commun. 2002;294(3):597-601.

16. Fu M, Zhang J, Lin Y, Zhu X, Ehrengruber MU, Chen YE. Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-gamma 1 gene expression in human aortic smooth muscle cells. J Biol Chem. 2002;277(30):26808-14.

17. Zhang J, Fu M, Zhu X, Xiao Y, Mou Y, Zheng H, Akinbami MA, Wang Q, Chen YE. Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells. J Biol Chem. 2002;277(13):11505-12.

18. Fu M, Zhu X, Wang Q, Zhang J, Song Q, Zheng H, Ogawa W, Du J, Chen YE.Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway. Circ Res. 2001;89(11):1058-64.

19. Fu M, Zhang J, Zhu X, Myles DE, Willson TM, Liu X, Chen YE. Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem. 2001;276(49):45888-94.