Consultant, Nonhuman Primate Research Center
Director, Physiology Programs and Laboratories
Department of Cell Biology and Molecular Medicine
New Jersey Medical School
University of Medicine and Dentistry of New Jersey
Selected publications regarding non-human primates:
1.Shen Y-T, Vatner DE, Gagnon HE, Vatner SF: Species differences in regulation of a-adrenergic receptor function. Am J Physiol 257:R1110-R1116, 1989.
2.Shen Y-T, Young MA, Ohanian J, Graham RM, Vatner, SF: Atrial natriuretic factor induced systemic vasoconstriction in conscious dogs, rats, and monkeys. Circulation Research 66:647-661, 1990.
3.Knight DR, Shen Y-T, Young MA, Vatner SF: Acetylcholine induced coronary vasoconstriction and vasodilation in tranquilized baboons. Circulation Research 69:706-713, 1991.
4.Sato N, Kiuchi K, Shen Y-T, Vatner SF, Vatner DE: Adrenergic responsiveness is reduced, while baseline cardiac function is preserved in old adult conscious monkeys. Am J Physiol 269(Heart Circ. Physiol 38):H1664-H1671, 1995
5.Shen Y-T, Fallon JT, Iwase M, Vatner SF: Innate protection of baboon myocardium following coronary artery occlusion and reperfusion. Am J Physiol 270(Heart Circ. Physiol. 39):H1812-H1818, 1996
6.Cui T, Shen Y-T, Kalthof B, Iwase M, Vatner SF, Vatner DE: Identification and functional role of b-adrenergic receptor subtypes in primate and rodent: in vivo vs. isolated myocytes. J Mol Cell Cardiol 28(6):1307-1317, 1996
7.Ghaleh B, Shen Y-T, Vatner SF: Spatial heterogeneity of myocardial blood flow presages salvage vs. necrosis with coronary artery reperfusion in conscious baboons. Circulation 94:2210-2215, 1996
8.Shen Y-T, Cervoni P, Claus T, Vatner SF: Differences in ?3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs. J Pharmacol Exp Ther 278:1435-1443, 1996
9.Shannon RP, Mathier MA, Manders WT, Shen Y-T: Coronary vascular responses to acute cocaine administration in conscious baboons compared to dogs. J Am Coll Cardiol35:1347-1354, 2000
10.Asai K, Kudej RK, Shen Y-T, Yang G-P, Takagi G, Kudej AB, Geng Y-J, Nazareno JB, Vatner DE, Natividad F, Bishop S, Vatner SF: Peripheral vascular endothelial dysfunction and apoptosis in old monkeys. Arterioscler Thromb Vasc Biol 20:1493-1499, 2000
11.Asai K, Kudej RK, Takagi G, Kudej AB, Natividad F, Y-T Shen, Vatner DE, Vatner SF: Paradoxically enhanced endothelin-B receptor-mediated vasoconstriction in conscious old monkeys. Circulation 103:2382-2386, 2001
12.Takagi G, Asai K, Vatner SF, Kudej RK, Takagi I, Resuello RRG, Natividad F, Shen Y-T, Vatner DE: Gender differences on the effects of aging on cardiac and peripheral ?-adrenergic receptor stimulation in old conscious monkeys. Am J Physiol Heart Circ Physiol 285:H527-H534, 2003