澳门新葡8455最新网站-点击进入

 

研究方向

人类的再生能力远不如一些低等动物,例如,斑马鱼心脏可以再生、蝾螈断臂可以再生,等等。近几年来,干细胞和体细胞重编程技术的发展使得人类有望通过诱导细胞命运重编程从而获得自体来源的多种功能细胞类型(例如心肌细胞、肝脏细胞、胰岛细胞、神经元等等),进而有望实现组织器官的再生和修复。这种再生医疗的新策略为解决一些退行性疾病以及一些难以治愈的重大疾病(例如心肌梗塞、肝衰竭、糖尿病、老年痴呆症等)带来了新希望。

本实验室基于小分子诱导细胞重编程的研究基础,主要针对心脏、肝脏等重大器官的损伤及慢性纤维化过程,开发原位诱导细胞重编程的再生新策略,为治疗心肌梗塞、肝纤维化/肝硬化、肝癌等疾病提供全新的解决方案及候选小分子药物具体研究内容包括:(1小分子化合物诱导心脏原位再生;(2小分子化合物诱导肝脏原位再生;(3)心脏和肝脏纤维化过程中的细胞命运转化及其调控;4)肿瘤细胞重编程的新药研发5小分子诱导细胞命运重编程的分子机制和小分子筛选新技术(基于细胞图像机器学习的细胞谱系追踪、高通量靶向转录组测序等)

研究室成员

研究员PI: 赵扬 PhD Email: yangzhao@pku.edu.cn

行政助理:唐殿红 dianhongtang@pku.edu.cn

博士后

刘洋PhD Emailyangterryliu@163.com

席广银PhD Emailxiguangyin612@163.com

研究生(www.8455.com):

赵宏

杨正浩

白云飞

杨晓淳

杨春艳

毛利超

林鹏燕

吴靖东

杨峻博

研究生(前沿交叉学科研究院):

李军

陶言梦

年欣欣

叶灿

杨洋

本科实习生:

熊岳汉

古丽妮葛尔

朱擎国

辛媛媛

吴曼绮

实验室地址: 澳门新葡8455最新网站-点击进入王克桢楼2207208

联系电话: 010-62766138

 

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赵扬研究员部分代表性文章(*通讯作者):

1. Ye, J., Ge, J., Zhang, X., Cheng, L., Zhang, Z.Y., He, S., Wang, Y., Lin, H., Yang, W.F., Liu, J.F., Zhao, Y. *, Deng, H.K.* (2016) Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds. Cell Research. 26(1):34-45.

2. Zhao, Y. *, Zhao, T, Guan, J.Y., Zhang, X., Fu, Y., Ye, J.Q., Zhu, J.L., Meng, G.F., Ge, J., Yang, S.S., Cheng, L., Du, Y.Q., Zhao, C.R., Wang, T., Su, L.L., Yang, W.F., Deng, H.K.* (2015) A XEN-like state bridges the cell fate transition of fibroblasts to pluripotency during chemical reprogramming. Cell. 17;163(7):1678-91. (封面论文,入选中国科协评选的中国生命科学领域十大科技进展,《中国科学》杂志评选的“Cell杂志2015中国年度论文。)

3. Li, X., Zuo, X.H., Jing, J.Z., Ma, Y.T., Wang, J.M., Liu, D.F., Zhu, J.L., Du, X.M., Xiong, L., Du, Y.Y., Xu, J., Xiao, X., Wang, J.L., Chai, Z.*, Zhao, Y. *, Deng, H.K*. (2015) Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 17(2): p. 195-203. (封面论文)

4. Fang, R.G., Liu. K., Zhao, Y. (Co-first author), Li, H.B., Zhu, D.C., Du, Y.Y., Xiang, C.G., Li, X., Liu, H.S., Miao, Z.C., Zhang, X., Shi, Y., Yang, W.F., Xu, J., Deng, H.K. (2014) Generation of Naive Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts. Cell Stem Cell, 15(4): p. 488-496.

5. Hou, P.P., Li, Y.Q., Zhang, X., Liu, C., Guan, J.Y., Li, H.G., Zhao, T., Ye, J.Q., Yang, W.F., Liu, K., Ge, J., Xu, J., Zhang, Q., Zhao, Y.*, Deng, H.K*. (2013) Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds. Science, 341(6146): p. 651-654. (入选科技部评选“2013年度中国科学十大进展和教育部评选的“2013年度中国高校十大科技进展。)

6. Shu, J., Wu, C., Wu, Y.T., Li, Z.Y., Shao, S.D., Zhao, W.H., Tang, X., Yang, H., Shen, L.J ., Zuo, X.H., Yang, W.F., Shi, Y., Chi, X.C., Zhang, H.Q., Gao, G., Shu, Y.M., Yuan, K.H ., He, W.W., Tang, C.*, Zhao, Y., Deng, H.K.* Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers. CELL, 2013. 153(5): p. 963-975. (封面论文)

7. Li, Y.Q., Zhang, Q.A., Yin, X.L., Yang, W.F., Du, Y.Y., Hou, P.P., Ge, J.A., Liu, C., Zhang, W.Q., Zhang, X., Wu, Y.T., Li, H.G., Liu, K., Wu, C., Song, Z.H., Zhao, Y.*, Shi, Y.*, Deng, H.K.* (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research, 21(1): p. 196-204.

8. Zhao, Y., Yin, X.L., Qin, H., Zhu, F.F., Liu, H.S., Yang, W.F., Zhang, Q., Xiang, C.A., Hou, P.P., Song, Z.H., Liu, Y.X., Yong, J., Zhang, P.B., Cai, J., Liu, M., Li, H.G., Li, Y.Q., Qu, X.X., Cui, K., Zhang, W.Q., Xiang, T.T., Wu, Y.T., Zhao, Y.D., Liu, C., Yu, C., Yuan, K.H., Lou, J.N., Ding, M.X., Deng, H.K. (2008) Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation. Cell Stem Cell, 3(5): p. 475-479.

9. Cai, J., Zhao, Y. (Co-first author), Liu, Y.X., Ye, F., Song, Z.H., Qin, H., Meng, S., Chen, Y.Z., Zhou, R.D., Song, X.J., Guo, Y.S., Ding, M.X., Deng, H.K. (2007) Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology, 45(5): p. 1229-1239.