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细胞应激与稳态调控研究室

课题组致力于研究细胞应激和稳态调控的机制及其生理病理意义。目前主要关注于细胞如何感知到营养物质(如氨基酸)匮并进行代谢调控响应以及DNA 6mA甲基化参与高等生物细胞应激的功能和机制。 

详细信息请见实验室网页

实验室网页:

联系方式

研究室主任(PI)刘颖 研究员 Ph.D email: ying.liu@pku.edu.cn

科研助理王维兰 email: nancy8270@126.com

实验室地址澳门新葡8455最新网站-点击进入综合科研楼219、231室

 

代表性文章

1. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife (2019) e41792.

2. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology 21(2019) 319-327.

3. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signaling to promote tumorigenesis and ageing. Nature 557(2018) 585-589.

4. Chen J#, Ou Y#, Li Y, Hu S, Shao LW and Liu Y*. Metformin Extends C. elegans Lifespan through Lysosomal Pathway. eLife 6 (2017) e31268.

5. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res. 11 (2016) 1182-1196. (cover story)

6. Berendzen K, Durieux J, Shao L, Tian Y, Kim H, Wolff S, Liu Y and Dillin A*. Neuroendocrine coordination of mitochondrial stress signaling and proteostasis. Cell 166 (2016) 1553-1563.

7. Liu Y, Samuel B, Breen P, and Ruvkun G*. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508 (2014) 406-410.

8. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q*. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Mol. Cell 44 (2011) 502-508.

9. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q*. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941 (2009) 750-753.